Toll-like-Rezeptor 3
Das TLR3-Gen kodiert den Toll-like-Rezeptor 3 der als Bestandteil der angeborenen Immunität in den Phagolysosomen die doppelstängige RNA detektiert und über eine Signalkaskade die Interferon 1 Produktion anregt. Mutationen führen zu einer vermehrten Anfälligkeit gegenüber Herpes-Enzephalitis und COVID-19.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Yang Z et al. (2008) Toll-like receptor 3 and geographic atrophy in age-related macular degeneration.
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2. |
Mørk N et al. (2015) Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.
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3. |
Hu YH et al. (2015) WDFY1 mediates TLR3/4 signaling by recruiting TRIF.
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4. |
Lim HK et al. (2014) TLR3 deficiency in herpes simplex encephalitis: high allelic heterogeneity and recurrence risk.
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5. |
Verstak B et al. (2013) An alanine-to-proline mutation in the BB-loop of TLR3 Toll/IL-1R domain switches signalling adaptor specificity from TRIF to MyD88.
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6. |
Gorbea C et al. (2013) Depletion of the 26S proteasome adaptor Ecm29 increases Toll-like receptor 3 signaling.
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7. |
Zhang SY et al. (2013) TLR3 immunity to infection in mice and humans.
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8. |
Sironi M et al. (2012) A common polymorphism in TLR3 confers natural resistance to HIV-1 infection.
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9. |
Guo Y et al. (2011) Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity.
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10. |
Ives A et al. (2011) Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis.
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11. |
Zhou Y et al. (2010) A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages.
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12. |
Bsibsi M et al. (2010) The microtubule regulator stathmin is an endogenous protein agonist for TLR3.
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13. |
Lai Y et al. (2009) Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury.
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14. |
Allikmets R et al. (2009) Geographic atrophy in age-related macular degeneration and TLR3.
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15. |
Edwards AO et al. (2009) Geographic atrophy in age-related macular degeneration and TLR3.
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16. |
None (2009) Geographic atrophy in age-related macular degeneration and TLR3.
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17. |
Kadowaki N et al. (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
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18. |
Liu L et al. (2008) Structural basis of toll-like receptor 3 signaling with double-stranded RNA.
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19. |
Kleinman ME et al. (2008) Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.
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20. |
Zhang SY et al. (2007) TLR3 deficiency in patients with herpes simplex encephalitis.
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21. |
Bell JK et al. (2006) The dsRNA binding site of human Toll-like receptor 3.
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22. |
Choe J et al. (2005) Crystal structure of human toll-like receptor 3 (TLR3) ectodomain.
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23. |
Li K et al. (2005) Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes.
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24. |
Schulz O et al. (2005) Toll-like receptor 3 promotes cross-priming to virus-infected cells.
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25. |
Meylan E et al. (2004) RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.
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26. |
Doyle S et al. (2002) IRF3 mediates a TLR3/TLR4-specific antiviral gene program.
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27. |
Alexopoulou L et al. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
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28. |
Zhang Q et al. (2020) Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
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29. |
Muzio M et al. (2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells.
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30. |
Rock FL et al. (1998) A family of human receptors structurally related to Drosophila Toll.
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31. |
Delgado MF et al. (2009) Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease.
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Update: 23. Juni 2025