Toll-like-Rezeptor 4

Clark SR et al. (2007) Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood.

Nakajima T et al. (2008) Natural selection in the TLR-related genes in the course of primate evolution.

Carvalho A et al. (2008) Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis.

Weindl G et al. (2007) Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling.

Seki E et al. (2007) TLR4 enhances TGF-beta signaling and hepatic fibrosis.

Ferwerda B et al. (2007) TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans.

Vogl T et al. (2007) Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock.

Awomoyi AA et al. (2007) Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children.

Apetoh L et al. (2007) Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.

Tulic MK et al. (2007) TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide.

Ohto U et al. (2007) Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa.

Bochud PY et al. (2008) Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation.

Cao CX et al. (2007) Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice.

Seimon TA et al. (2006) Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.

Zhang X et al. (2006) Toll-like receptor 4 deficiency causes pulmonary emphysema.

Shi H et al. (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance.

Zacharowski K et al. (2006) Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome.

Blander JM et al. (2006) Toll-dependent selection of microbial antigens for presentation by dendritic cells.

Mockenhaupt FP et al. (2006) Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria.

Seo KW et al. (2005) Protective role of interleukin-10 promoter gene polymorphism in the pathogenesis of invasive pulmonary aspergillosis after allogeneic stem cell transplantation.

Zareparsi S et al. (2005) Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration.

Tanga FY et al. (2005) The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy.

Andonegui G et al. (2009) Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection.

Tang AT et al. (2017) Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.

Millien VO et al. (2013) Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4.

Ohto U et al. (2012) Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I.

Hayashi C et al. (2012) Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen.

Figueroa L et al. (2012) The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF.

Henao-Mejia J et al. (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.

Zanoni I et al. (2011) CD14 controls the LPS-induced endocytosis of Toll-like receptor 4.

Gray P et al. (2010) Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling.

Maroso M et al. (2010) Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures.

St John AL et al. (2009) Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines.

Hawn TR et al. (2005) Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease.

Bochud PY et al. (2009) Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy.

Hammad H et al. (2009) House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells.

Park BS et al. (2009) The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex.

Asakura Y et al. (2009) Toll-like receptor 4 polymorphisms and aspergillosis.

Cervera C et al. (2009) Toll-like receptor 4 polymorphisms and aspergillosis.

Levitz SM et al. (2009) Toll-like receptor 4 polymorphisms and aspergillosis.

Deng J et al. (2009) Toll-like receptors 4 and 5 induce distinct types of vasculitis.

Trompette A et al. (2009) Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein.

Mossman KL et al. (2008) Cutting edge: FimH adhesin of type 1 fimbriae is a novel TLR4 ligand.

None (2008) TLR polymorphisms and the risk of invasive fungal infections.

Zhang D et al. (2015) Neutrophil ageing is regulated by the microbiome.

Hu YH et al. (2015) WDFY1 mediates TLR3/4 signaling by recruiting TRIF.

Doyle S et al. (2002) IRF3 mediates a TLR3/TLR4-specific antiviral gene program.

Shirey KA et al. (2013) The TLR4 antagonist Eritoran protects mice from lethal influenza infection.

Rolls A et al. (2007) Toll-like receptors modulate adult hippocampal neurogenesis.

Boraska Jelavić T et al. (2006) Microsatelite GT polymorphism in the toll-like receptor 2 is associated with colorectal cancer.

Supajatura V et al. (2002) Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity.

Wolfs TG et al. (2002) In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation.

Re F et al. (2001) Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells.

Harju K et al. (2001) Ontogeny of Toll-like receptors Tlr2 and Tlr4 in mice.

Aderem A et al. (2000) Toll-like receptors in the induction of the innate immune response.

None (1968) Genetic control of leucocyte responses to endotoxin.

Jiang D et al. (2005) Regulation of lung injury and repair by Toll-like receptors and hyaluronan.

Blander JM et al. (2004) Regulation of phagosome maturation by signals from toll-like receptors.

West AP et al. (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.

Muzio M et al. (2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells.

Rock FL et al. (1998) A family of human receptors structurally related to Drosophila Toll.

Kasturi SP et al. (2011) Programming the magnitude and persistence of antibody responses with innate immunity.

Delgado MF et al. (2009) Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease.

Kadowaki N et al. (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.

Roger T et al. () MIF regulates innate immune responses through modulation of Toll-like receptor 4.

Kane M et. al. (2011) Successful transmission of a retrovirus depends on the commensal microbiota.

Bochkov VN et al. (2002) Protective role of phospholipid oxidation products in endotoxin-induced tissue damage.

Balistreri CR et al. (2004) Role of Toll-like receptor 4 in acute myocardial infarction and longevity.

Li Q et al. (2004) Toll-like receptor 4 mutation impairs the macrophage TNFalpha response to peptidoglycan.

Michelsen KS et al. (2004) Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.

Hsu LC et al. (2004) The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.

Brinkmann V et al. (2004) Neutrophil extracellular traps kill bacteria.

Oyama J et al. (2004) Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice.

Hollestelle SC et al. (2004) Toll-like receptor 4 is involved in outward arterial remodeling.

Smirnova I et al. (2003) Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility.

Andonegui G et al. (2003) Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs.

Malley R et al. (2003) Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection.

Pasare C et al. (2005) Control of B-cell responses by Toll-like receptors.

Kiechl S et al. (2002) Toll-like receptor 4 polymorphisms and atherogenesis.

Nagai Y et al. (2002) Essential role of MD-2 in LPS responsiveness and TLR4 distribution.

Lorenz E et al. (2002) Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock.

Kurt-Jones EA et al. (2000) Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.

Arbour NC et al. (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.

Rehli M et al. (2000) PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene.

Frantz S et al. (1999) Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium.

Poltorak A et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

Medzhitov R et al. (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.

Michalek SM et al. (1980) The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxim.