Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Cytochrom P450 2B6

Gentests:

Klinisch Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Multiplex ligationsabhängige Amplifikation
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Referenzen:

1.

Trask B et al. (1993) Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.

external link
2.

Paolini M et al. (1999) Co-carcinogenic effect of beta-carotene.

external link
3.

Thum T et al. (2000) Gene expression in distinct regions of the heart.

external link
4.

Tsuchiya K et al. (2004) Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens.

external link
5.

Haas DW et al. (2004) Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study.

external link
6.

Cressey TR et al. (2007) Pharmacogenetics of antiretroviral drugs for the treatment of HIV-infected patients: an update.

external link
7.

Blievernicht JK et al. (2007) MALDI-TOF mass spectrometry for multiplex genotyping of CYP2B6 single-nucleotide polymorphisms.

external link
8.

Davaalkham J et al. (2009) Allele and genotype frequencies of cytochrome P450 2B6 gene in a Mongolian population.

external link
9.

Watanabe T et al. (2010) Functional characterization of 26 CYP2B6 allelic variants (CYP2B6.2-CYP2B6.28, except CYP2B6.22).

external link
10.

Carr DF et al. (2010) Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort.

external link
11.

Elens L et al. (2010) Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients.

external link
12.

Radloff R et al. (2013) Novel CYP2B6 enzyme variants in a Rwandese population: functional characterization and assessment of in silico prediction tools.

external link
13.

Yamano S et al. (1989) cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver.

external link
14.

Miles JS et al. (1988) A novel human cytochrome P450 gene (P450IIB): chromosomal localization and evidence for alternative splicing.

external link
15.

Santisteban I et al. (1988) The major phenobarbital-inducible cytochrome P-450 gene subfamily (P450IIB) mapped to the long arm of human chromosome 19.

external link
16.

Mizukami Y et al. (1983) Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver.

external link
Update: 23. Juni 2025
Copyright © 2005-2025 Zentrum für Nephrologie und Stoffwechsel, Dr. Mato Nagel
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Deutschland, Tel.: +49-3576-287922, Fax: +49-3576-287944
Seitenüberblick | Webmail | Haftungsausschluss | Datenschutz | Impressum