Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The TICAM2 gene encodes a protein, TIR domain-containing adapter molecule 2, that is an adaptor protein involved in Toll receptor signaling of the innate immunity.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Bin LH et al. (2003) TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. 
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| 2. |
Fitzgerald KA et al. (2003) LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
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| 3. |
Yamamoto M et al. (2003) TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.
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| 4. |
McGettrick AF et al. (2006) Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
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