Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The ZBP1 gene encodes a protein, Z-DNA-binding protein 1, that plays a role in innate immunity by detecting foreign DNA and inducing a type-1 interferone response.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Schwartz T et al. (1999) Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA. 
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| 2. |
Fu Y et al. (1999) Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display.
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| 3. |
Rothenburg S et al. (2002) Complex regulation of the human gene for the Z-DNA binding protein DLM-1.
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| 4. |
Takaoka A et al. (2007) DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
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| 5. |
Wang R et al. (2020) Gut stem cell necroptosis by genome instability triggers bowel inflammation.
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| 6. |
Jiao H et al. (2020) Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation.
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