Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The TNS2 gene encodes a protein, tensin-2, that binds to actin filaments and participates in regulating cell migration.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Kikuno R et al. (1999) Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. 
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| 2. |
Chen H et al. (2002) Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration.
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| 3. |
Hafizi S et al. (2002) Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.
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| 4. |
Cho AR et al. (2006) Deficiency of the tensin2 gene in the ICGN mouse: an animal model for congenital nephrotic syndrome.
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| 5. |
Jung AS et al. (2011) Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling.
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| 6. |
Moon KD et al. (2012) The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2.
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