Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
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Glutathione S-transferase P

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Multiplex Ligation-Dependent Probe Amplification
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

References:

1.

Board PG et al. (1989) Isolation of a cDNA clone and localization of the human glutathione S-transferase 3 genes to chromosome bands 11q13 and 12q13-14.

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2.

Menegon A et al. (1998) Parkinson's disease, pesticides, and glutathione transferase polymorphisms.

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3.

None (1998) Parkinson's disease: nature meets nurture.

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4.

Ali-Osman F et al. (1997) Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins.

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5.

Board P et al. (1993) Evidence against a relationship between fatty acid ethyl ester synthase and the Pi class glutathione S-transferase in humans.

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6.

Smith CM et al. (1995) Genetic and radiation-reduced somatic cell hybrid sublocalization of the human GSTP1 gene.

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7.

None (1981) Biochemical genetics of glutathione-S-transferase in man.

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8.

Silberstein DL et al. (1982) Gene for glutathione S-transferase-1 (GST1) is on human chromosome 11.

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9.

Laisney V et al. (1983) [Localization of the LDHA-GST3-ESA4 synthetic group on human chromosome 11. Analyses of the classic man-rodent hybrids and of a new type (not adhering to the wall)].

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10.

Suzuki T et al. (1984) Glutathione-S-transferase gene mapped to chromosome 11 is GST3 not GST1.

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11.

Laisney V et al. (1984) Human genes for glutathione S-transferases.

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12.

Kano T et al. (1987) Structure and expression of a human class pi glutathione S-transferase messenger RNA.

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13.

Beutler E et al. (1988) Erythrocyte glutathione S-transferase deficiency and hemolytic anemia.

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14.

Moscow JA et al. (1988) Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer.

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15.

Islam MQ et al. (1989) Chromosomal localization of human glutathione transferase genes of classes alpha, mu and pi.

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16.

Zusterzeel PL et al. (1999) Glutathione S-transferase isoenzymes in decidua and placenta of preeclamptic pregnancies.

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17.

Kingsley DM et al. (1989) A molecular genetic linkage map of mouse chromosome 9 with regional localizations for the Gsta, T3g, Ets-1 and Ldlr loci.

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18.

Morrow CS et al. (1989) Structure of the human genomic glutathione S-transferase-pi gene.

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19.

Moscow JA et al. (1989) Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors.

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20.

Konohana A et al. (1990) Placental glutathione-S-transferase-pi mRNA is abundantly expressed in human skin.

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21.

Bora PS et al. (1991) Molecular cloning, sequencing, and expression of human myocardial fatty acid ethyl ester synthase-III cDNA.

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22.

Wilk JB et al. (2006) Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: the GenePD Study.

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23.

Seldin MF et al. (1991) A proximal mouse chromosome 9 linkage map that further defines linkage groups homologous with segments of human chromosomes 11, 15, and 19.

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24.

Gilliland FD et al. (2004) Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study.

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25.

Board PG et al. (1992) The human Pi class glutathione transferase sequence at 12q13-q14 is a reverse-transcribed pseudogene.

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26.

Rochelle JM et al. (1992) A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus.

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27.

Zusterzeel PL et al. (2002) Paternal contribution to the risk for pre-eclampsia.

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28.

Allan JM et al. (2001) Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia.

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29.

Henderson CJ et al. (2000) Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi.

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Update: June 23, 2025
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