Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Multiplex Ligation-Dependent Probe Amplification |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Wang X et al. (2002) Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight. 
|
| 2. |
Chen H et al. (1996) Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect.
|
| 3. |
Lee KA et al. (2001) Increased frequencies of glutathione S-transferase (GSTM1 and GSTT1) gene deletions in Korean patients with acquired aplastic anemia.
|
| 4. |
Chen CL et al. (1996) Simultaneous characterization of glutathione S-transferase M1 and T1 polymorphisms by polymerase chain reaction in American whites and blacks.
|
| 5. |
Wiebel FA et al. (1999) The hereditary transmission of the glutathione transferase hGSTT1-1 conjugator phenotype in a large family.
|
| 6. |
Hallier E et al. (1990) Glutathione conjugation and cytochrome P-450 metabolism of methyl chloride in vitro.
|
| 7. |
Peter H et al. (1989) Metabolism of methyl chloride by human erythrocytes.
|
| 8. |
Pemble S et al. (1994) Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism.
|
| 9. |
Schröder KR et al. (1995) Glutathione-S-transferase (GST) theta polymorphism influences background SCE rate.
|
| 10. |
Webb G et al. (1996) Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1).
|
 |
Copyright © 2005-2025 by Center for Nephrology and Metabolic Disorders, Dr. Mato Nagel, MD Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Germany, Tel.: +49-3576-287922, Fax: +49-3576-287944 Sitemap | Webmail | Disclaimer | Privacy Issues | Website Credits |