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Center for Nephrology and Metabolic Disorders
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Hyperphosphaturia

Hyperphosphaturia is renal phosphate wastage. It frequently results in hypophosphatemia. Also osteoporosis and nephrocalcinosis can be observed.

Physiology

G a1 Oral intake 1400mg/d b1 Bone b0 Bowel a1->b0 a6 Bone resorption 210mg/d b1->a6 a0 Extracellular fluid plasma concentration 0,8-1,44 mmol/l a5 Bone building 210mg/d a5->b1 a6->a0 a4 Enteral secretion 210mg/d a4->b0 a7 Renal  filtration 6000-7000mg/d b2 Kidney a7->b2 a0->a5 a0->a4 a0->a7 a3 Enteral resorption 1120mg/d b0->a3 a2 Enteral excretion 490mg/d b0->a2 a8 Renal reabsorption 4800-6300mg/d b2->a8 a9 Renal excretion 1,4-1400mg/d b2->a9 a3->a0 a8->a0
Phosphat metabolism

Diseases

Dent disease
Hyperphosphaturia is sometimes difficult to measure. However, it is of cardinal importance to the development of nephrocalcinosis and hypophaspatemia related bone disease.
Fanconi renotubular syndrome 2
Renal phosphate wasting is observed along with other symptoms of proximal tubular damage..
Hypophosphatemic rickets with hyperparathyroidism
Hyperphosphaturia is caused by downregulation of phosphate transporters.
Osteoglophonic dysplasia
Hyperphosphaturie is caused by disrupted intracellular signaling in proximal tubulus cells.
Update: June 23, 2025
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