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Toll-like receptor 3

The TLR3 gene encodes a toll-like receptor which as an important component of innate immunity senses double stranded RNA in phagolysosomes. Mutations cause susceptibility to Herpes encephalitis and COVID-19.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Susceptibility to herpes-specific encephalopathy 02
TLR3
hiv1_infection_resistance_to
TLR3

References:

1.

Yang Z et al. (2008) Toll-like receptor 3 and geographic atrophy in age-related macular degeneration.

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2.

Mørk N et al. (2015) Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.

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3.

Hu YH et al. (2015) WDFY1 mediates TLR3/4 signaling by recruiting TRIF.

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4.

Lim HK et al. (2014) TLR3 deficiency in herpes simplex encephalitis: high allelic heterogeneity and recurrence risk.

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5.

Verstak B et al. (2013) An alanine-to-proline mutation in the BB-loop of TLR3 Toll/IL-1R domain switches signalling adaptor specificity from TRIF to MyD88.

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6.

Gorbea C et al. (2013) Depletion of the 26S proteasome adaptor Ecm29 increases Toll-like receptor 3 signaling.

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7.

Zhang SY et al. (2013) TLR3 immunity to infection in mice and humans.

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8.

Sironi M et al. (2012) A common polymorphism in TLR3 confers natural resistance to HIV-1 infection.

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9.

Guo Y et al. (2011) Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity.

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10.

Ives A et al. (2011) Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis.

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11.

Zhou Y et al. (2010) A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages.

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12.

Bsibsi M et al. (2010) The microtubule regulator stathmin is an endogenous protein agonist for TLR3.

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13.

Lai Y et al. (2009) Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury.

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14.

Allikmets R et al. (2009) Geographic atrophy in age-related macular degeneration and TLR3.

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15.

Edwards AO et al. (2009) Geographic atrophy in age-related macular degeneration and TLR3.

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16.

None (2009) Geographic atrophy in age-related macular degeneration and TLR3.

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17.

Kadowaki N et al. (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.

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18.

Liu L et al. (2008) Structural basis of toll-like receptor 3 signaling with double-stranded RNA.

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19.

Kleinman ME et al. (2008) Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.

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20.

Zhang SY et al. (2007) TLR3 deficiency in patients with herpes simplex encephalitis.

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21.

Bell JK et al. (2006) The dsRNA binding site of human Toll-like receptor 3.

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22.

Choe J et al. (2005) Crystal structure of human toll-like receptor 3 (TLR3) ectodomain.

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23.

Li K et al. (2005) Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes.

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24.

Schulz O et al. (2005) Toll-like receptor 3 promotes cross-priming to virus-infected cells.

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25.

Meylan E et al. (2004) RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.

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26.

Doyle S et al. (2002) IRF3 mediates a TLR3/TLR4-specific antiviral gene program.

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27.

Alexopoulou L et al. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.

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28.

Zhang Q et al. (2020) Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

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29.

Muzio M et al. (2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells.

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30.

Rock FL et al. (1998) A family of human receptors structurally related to Drosophila Toll.

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31.

Delgado MF et al. (2009) Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease.

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Update: June 23, 2025
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