Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The IRF3-Gene encodes a protein that is an element of the signal cascade that controls transcription of interferon alpha and beta as well as many other interferon-related genes. Mutations cause autosomal dominant susceptibility to herpes encephalitis and COVID-19.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Escalante CR et al. (2007) Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer. 
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| 2. |
Huai W et al. (2019) KAT8 selectively inhibits antiviral immunity by acetylating IRF3.
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| 3. |
Andersen LL et al. (2015) Functional IRF3 deficiency in a patient with herpes simplex encephalitis.
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| 4. |
Liu S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
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| 5. |
Chen HW et al. (2013) The roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus.
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| 6. |
Sun L et al. (2013) Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
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| 7. |
Wu J et al. (2013) Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
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| 8. |
Bigham AW et al. (2011) Host genetic risk factors for West Nile virus infection and disease progression.
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| 9. |
Manel N et al. (2010) A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells.
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| 10. |
Menachery VD et al. (2010) Interferon regulatory factor 3-dependent pathways are critical for control of herpes simplex virus type 1 central nervous system infection.
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| 11. |
Zhang Q et al. (2020) Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
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| 12. |
Stetson DB et al. (2006) Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.
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| 13. |
Foy E et al. (2003) Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease.
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| 14. |
Sharma S et al. (2003) Triggering the interferon antiviral response through an IKK-related pathway.
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| 15. |
Bellingham J et al. (1998) Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker.
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| 16. |
Wathelet MG et al. (1998) Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo.
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| 17. |
Weaver BK et al. (1998) Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1.
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| 18. |
Au WC et al. (1995) Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.
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| 19. |
Mørk N et al. (2015) Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.
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| 20. |
Doyle S et al. (2002) IRF3 mediates a TLR3/TLR4-specific antiviral gene program.
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